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Vertically crossingthe image is an arteriole (A)with aclearlyvisible layer ofcircularly arranged smooth muscle cells (5M).Thisarterioleis crossed perpendicularly by a venule (\/). The doxycycline treatment trial for humanprion disease in Italy and France completed in 2013 and didnot show any positive effect in survival or other outcomes.(www.agenziafarmaco.it/en).
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